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LAICON 2022: International - Statin Intolerance

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D Prabhakar, Chennai    01 November 2022

  • Statins are the most common, widely prescribed first choice medication for lipid-lowering.
  • Inability to take statins to achieve the target LDL-C for the individual.
  • Inability is due to adverse effects or due to unacceptable elevation of liver enzymes or creative kinase levels.
  • Absence of factors that can provoke the adverse effects of statins.
  • Reversal on withdrawal.
  • Failure to tolerate statins despite rechallenge.
  • Intolerance to at least two statins – one at the lowest starting dose and another at any dose.
  • Statin associated muscle side effects: The entire spectrum of muscular symptoms related to statin intake are now termed as statin associated muscle symptoms; 60% of statin discontinuation.
  • Nutraceuticals are useful in:
  • Managing residual risk associated with lipids other than LDL-C
  • Managing nonlipid-mediated residual risk
  • Optimizing LDL-C treatment in statin intolerance
  • Optimizing LDL-C treatment when add-on therapies for statins are not available
  • Adjuncts to lifestyle for individuals at high lifetime risk of ASCVD.

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